Powerball is an American lottery game offered by 45 states, the District of Columbia, Puerto Rico and the U.S. Virgin Islands. It is coordinated by the Multi-State Lottery Association (MUSL). From its inaugural drawing on April 19, 1992, until August 21, 2021, Powerball drawings were held twice a week (Wednesday and Saturday); a third weekly drawing (held Mondays) was added on August 23, 2021. Drawings are held every Monday, Wednesday and Saturday evening at 10:59 p.m. Eastern Time, at Florida Lottery headquarters in Tallahassee.

Since October 7, 2015, the game has used a 5/69 (white balls) + 1/26 (Powerballs) matrix from which winning numbers are chosen, resulting in odds of 1 in 292,201,338 of winning a jackpot per play. Each play costs $2 or $3 with the Power Play option (originally, Powerball plays cost $1; when Power Play began, such games were $2). The official cutoff for ticket sales is 10:00 p.m. Eastern Time; some lotteries cut off sales earlier. The drawings are held at the Florida Lottery's studio in Tallahassee. Powerball's minimum advertised jackpot is $20 million (annuity); Powerball's annuity is paid in 30 graduated installments over 29 years, or winners may choose a lump sum payment instead (cash option). One lump sum payment will be less than the total of the 30 annual payments because with the annuity option each yearly payment is increased by 5%.

On February 8, 2023, Powerball produced the largest lottery jackpot in history which was won by a ticket purchased in Altadena, California.

The numbers were originally drawn in West Des Moines, Iowa, before moving to Universal Studios Florida in Orlando. Drawing to their current home in Tallahassee in 2012.